Commensal gut bacteria-derived microvesicles: Mediators of microbe-host crosstalk and vehicles for mucosal drug delivery

Prof. Simon Carding from Quadram Institute Bioscience, United Kingdom, will join the 2nd World Congress on Targeting Exosomes, which will be organized on October 15-16, 202,5, in Valencia, Spain, and give a presentation entitled "Commensal gut bacteria-derived microvesicles: Mediators of microbe-host crosstalk and vehicles for mucosal drug delivery".

Prof. Carding will highlight how bacterial extracellular vesicles (BEVs) derived from human commensal gut bacteria act as key signalling mediators between the gut microbiota and the host. He will present evidence from both in vitro and in vivo model systems demonstrating their ability to transmigrate the gut epithelium and disseminate widely via the blood and lymphatic systems to gain access to peripheral organs including the central nervous system. At the cellular level BEVs target interactions with innate immune cells including monocytes/macrophages, dendritic cells, and microglial cells to elicit regulatory, anti-inflammatory responses. BEVs are also found in the blood and can discriminate between healthy individuals and patients with chronic inflammatory disease. This work opens new perspectives on the role of commensal bacteria derived BEVs in maintaining immune and tissue homeostasis, as disease diagnostic/prognostic indicators, and as vehicles for the delivery of drugs and vaccines.