Elucidating the Interplay Between Glioblastoma-Derived EVs and Cardiovascular Health – Best Poster Presentations 2024

Deimantė Kulakauskienė from the Lithuanian University of Health Sciences has received the Best Poster Presentation Award at the First Conference on Targeting Extracellular Vesicles in Malta.

Her research, “The Investigation of Glioblastoma-Derived EVs Effect on Cells in the Cardiovascular System,” reveals that small EVs enhance mitochondrial activity in cardiomyocytes, while both small and large EVs inhibit endothelial cells.

Deimantė Kulakauskienė stated:

“Initial studies revealed significant changes in mitochondrial respiration in cardiovascular cells, and our team is continuing to investigate mitochondrial potential, network dynamics, and cristae morphology in cardiomyocytes and endothelial cells after exposure to tumor cell vesicles.”

“Our aim is to uncover the potential molecular mechanisms underlying these interactions. So far, we have conducted extensive studies on vesicles from glioblastoma cells due to their well-established association with peripheral vasculature. Additionally, we have begun exploring the cardiovascular effects of vesicles from other peripheral tumors, such as breast adenocarcinoma. We aim to contribute to the currently underexplored field of cardiac lesions associated with oncological diseases.”

This work offers new insights into the potential connections between cancer and cardiovascular anomalies, highlighting the transformative implications for future research in both fields. The scientific community thanks Deimantė for her important contribution to our understanding of extracellular vesicles.

 

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