Platelet-Derived Microvesicles as Mitochondrial Messengers: Reprogramming Immune Bioenergetics and Inflammation

Platelet-Derived Microvesicles as Mitochondrial Messengers: Reprogramming Immune Bioenergetics and Inflammation

Luc Boudreau, University of Moncton, Canada

We are pleased to announce that Prof. Luc Boudreau (University of Moncton, Canada) will join Targeting Extracellular Vesicles 2026 as a speaker. Prof. Boudreau will present on the strategic topic: Platelet-Derived Microvesicles as Mitochondrial Messengers: Reprogramming Immune Bioenergetics and Inflammation.

Prof. Luc Boudreau leads research focused on the role of platelet-derived microvesicles (PMVs) in intercellular mitochondrial communication and immune regulation. His work demonstrates how PMVs transfer functional mitochondria to neutrophils, enhancing cellular bioenergetics, ATP production, mitochondrial activity, and inflammatory responses.

Prof. Luc’s studies further reveal that only intact mitochondrial transfer supports these effects, while dysfunctional PMVs fail to sustain cellular respiration and increase apoptotic signaling. In addition, his research highlights the delivery of active inflammatory enzymes, including 12-lipoxygenase and cyclooxygenase-1, by PMVs to neutrophils. These findings provide important insights into the mechanisms linking mitochondrial function, inflammation, and immune responses, with potential implications for inflammatory and immune-related diseases.