We are pleased to announce that Dr. Raghavan Pillai Raju from Augusta University, USA, will join Targeting Extracellular Vesicles 2026 as a speaker.

Aging causes a progressive physiological decline that increases susceptibility to injury, infection, and sepsis-related mortality. While young blood is known to possess transferable rejuvenating molecular factors, the specific vehicles and their components in the blood remain poorly understood. To investigate this, plasma small extracellular vesicles (EVs) from young and old mice were isolated and evaluated for their regenerative capabilities. The plasma EVs from young mice exerted a maturation-dependent protective effect against inflammation and sepsis. The study identified miRNAs that steadily decline in plasma-derived EVs post-maturation. The age-associated decline of these EV-derived miRNAs and their reparative effects highlights their therapeutic potential to counter systemic functional decline, demonstrating the critical role that plasma-derived EV cargo modifications play during aging and stress.