Gut-Microbiome Derived Extracellular Vesicles in Cancer

Gut microbiome-derived nanoparticles, known as bacterial extracellular vesicles (bEVs), have garnered interest as promising tools for studying the link between the gut microbiome and human health. The diverse composition of bEVs, including their proteins, mRNAs, metabolites, and lipids, makes them useful for investigating diseases such as cancer.

However, conventional approaches for studying gut microbiome composition alone may not be accurate in deciphering host-gut microbiome communication. Analyzing the functionality of bEVs could highlight the unique aspects of host-gut microbiome interactions in cancer patients.

There is a need to explore bEVs together with conventional gut microbiome analysis in functional cancer research to decipher the potential of bEVs as cancer diagnostic or therapeutic biomarkers.