Extracellular Vesicles in Cardio-Metabolic Therapy: Targeting Hypothalamic NLRP3 to Prevent Obesity-Linked Arrhythmias

Dr. Ramaroson Andriantsitohaina from the University of Montpellier, France will join the Second World Congress on Targeting Extracellular Vesicles and will give a presentation entitled "Extracellular Vesicles in Cardio-Metabolic Therapy: Targeting Hypothalamic NLRP3 to Prevent Obesity-Linked Arrhythmias".

His research elegantly bridges neuroscience, cardiology, and metabolic medicine by addressing how neuroinflammation in the hypothalamus contributes to metabolic dysfunction and cardiovascular disease.

Building on insights from the landmark CANTOS trial, Professor Andriantsitohaina's team has developed an innovative nanobiomedicine approach using neuron-specific small extracellular vesicles to deliver therapeutic agents across the blood-brain barrier. Their work specifically targets SF1 neurons within the ventromedial hypothalamus through intravenous administration of vesicles carrying NLRP3-DN, a dominant-negative mutant of the NLRP3 inflammasome.

This novel strategy represents a paradigm shift in our approach to obesity and related cardiovascular conditions by addressing the brain-adipose tissue-heart axis. By suppressing hypothalamic inflammation, his research aims to enhance brown adipose tissue thermogenesis, promote white adipose tissue "beiging," and stimulate cardioprotective adipokine release—ultimately improving cardiac function, reducing arrhythmic events, and attenuating atherosclerosis.

About Dr. Andriantsitohaina

Dr. Andriantsitohaina has been at the forefront of extracellular vesicle research since 2005, leading a dedicated research team focused on the isolation, characterization, and bioactive properties of EVs. With an impressive portfolio of 244 scientific publications and an H-index of 6, he has made significant contributions to our understanding of how EVs function in various pathological conditions, including sepsis, Crohn's disease, and metabolic syndrome.

Targeting EVs Congress
October 15-16, 2025 - Valencia, Spain
www.targeting-exosomes.com