Mitochondrial Damage-Associated Molecular Patterns in Extracellular Vesicles: Implications for Neuroinflammation in Neurodegenerative Disorders
Molecular mechanisms of EV-associated DAMPs-mediated neuroinflammation
A study led by Carla Lopes at the University of Coimbra investigated the role of extracellular vesicle-associated mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) in promoting early inflammation in neurodegenerative disorders.
The paper highlighted how dysfunctional mitochondria release mtDAMPs via mitochondrial-derived vesicles (MDVs), triggering neuroinflammation and contributing to neuronal death.
These findings underscore potential strategies for intervening in microglia-driven cerebral inflammation to delay disease onset, which she will present at Targeting EVs 2024.
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