Prof. Andriantsitohaina Wins Best Scientific Contribution 2024 for Nanotechnology Approach Using EVs to Target Obesity Regulation

Prof. Ramaroson Andriantsitohaina has been honored with the Best Scientific Contribution Award at the recent conference organized by the International Society of Microbiota and the World Mitochondria Society.

Prof. Andriantsitohaina’s research on engineered extracellular vesicles (sEVs) reveals their ability to target SF1 neurons in the ventromedial hypothalamus (VMH), effectively reducing body weight without altering food intake.

This approach offers new insights into obesity treatment and its related health conditions, potentially transforming therapeutic strategies for neurological diseases.

More about R Andriantsitohaina 

R Andriantsitohaina (Director of Research 1st class INSERM 244 publications, H index 59) research interest involved in the isolation, characterization and bioactions of Extracellular Vesicles (EV)s from different cohort (sepsis, Crohn, obstructive sleep apnea, preeclampsia, metabolic syndrome, obesity, diabetes). He is internationally recognized in the field of EVs and cardiovascular diseases.

  • Demonstration of a correlation between the increase of total circulating EVs with some EV subsets, endothelial dysfunction, vascular hyporeactivity and in the development of atherosclerosis.
  • EVs as potential biomarkers and biological vectors of obstructive sleep apnea-associated vascular impairment by promoting endothelial dysfunction and modifying its secretome, inflammation and vascular hyper-reactivity.
  • EVs bearing sonic hedgehog as a novel therapeutic approach in heart ischemia/reperfusion. Small EVs can be used for the selective delivery of therapeutic agents from the blood to the brain to target neurons involved in the regulation of energy balance such as food intake and energy expenditure, extending this exciting nanobiomedecine approach to potential applications for the treatment of obesity.

The scientific community extends its gratitude to Ramaroson for his exceptional contribution to this vital area of research.

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