Extracellular Vesicles in 2025: Shaping the Medicine of Tomorrow

A few lines about our studies:

Over the past 25 years, we have focused on the molecular mechanisms of aging and frailty at the MiniAging Research Group on Healthy Aging. Our favorite motto is: “adding years to life, but above all, life to years”. Our research aims to uncover the biological processes underlying this complex process to achieve healthy aging. Each of our projects is guided by the design of intervention strategies, ranging from nutrition, lifestyle, and physical exercise to pharmacological approaches and regenerative medicine. 

Our work has enabled us to identify innovative biomarkers through non-invasive imaging techniques, pioneer new research lines in regenerative medicine using extracellular vesicles derived from stem cells, and deepen the study of key longevity genes in centenarians and their descendants, such as Bcl-xL, in collaboration with national and international research groups.

These advances are reflected in more than 150 high-impact publications and in training new generations of researchers. We look to the future with a strong commitment: to develop diagnostic and therapeutic tools that allow for the early detection of frailty, the personalization of interventions, and the improvement of health throughout aging. In the coming years, transferring our knowledge into clinical practice will be our top priority.

At MiniAging, we reaffirm our goal: to generate scientific evidence that promotes active, healthy aging and a better quality of life for the entire population—because knowing how to age well is the work of a lifetime.

Introductory remarks:

It is a privilege to welcome you to Valencia for the Second World Congress on Targeting Extracellular Vesicles. This congress highlights the growing scientific significance of EVs as key mediators of intercellular communication, with broad implications for diagnostics, therapeutics, and systems biology. This year’s program involves various areas, such as the role of microbiota-derived EVs in brain and immune function, the interaction between mitochondria and EVs in aging and disease, and the impact of maternal EVs on early developmental metabolism. Beyond the scientific sessions, this meeting promotes interdisciplinary collaboration, providing valuable opportunities for researchers from different fields to exchange ideas, form partnerships, and collectively shape the future of EV-based science.