Redox Modulation in Aging Mediated by Stem Cell-derived Extracellular Vesicles

Cristina Mas-Bargues

University of Valencia, Spain

Dr. Cristina Mas-Bargues from the University of Valencia, Spain, will join the congress and give a presentation entitled: Redox Modulation in Aging Mediated by Stem Cell-derived Extracellular Vesicles.

Summary of Talk:

Dr. Cristina Mas-Bargues will highlight the critical importance of oxygen tension in stem cell culture and suggest that EVs from physioxic conditions hold therapeutic potential for mitigating oxidative damage, delaying senescence, and maintaining stemness in regenerative applications.

Questions Addressed in the Talk:

  • How does culturing stem cells under atmospheric oxygen (21% O₂) influence cellular aging and senescence?
  • What are the molecular and mitochondrial markers of oxidative stress-induced stem cell dysfunction?
  • How does oxygen tension affect the expression of core pluripotency factors (Oct4, Sox2, Klf4, c-Myc)?
  • What functional differences exist between extracellular vesicles (EVs) derived from physioxic (3% O₂) vs. normoxic (21% O₂) conditions?
  • Can EVs from stem cells cultured under physiological oxygen protect against oxidative stress and preserve stemness?
  • What implications do these findings have for improving stem cell-based therapies and culture protocols?
About Dr. Cristina Mas-Bargues:
Dr. Cristina Mas-Bargues is an Assistant Professor of Physiology at the University of Valencia, specializing in stem cell senescence, aging and regenerative medicine. Her research focuses on the role of extracellular vesicles (EVs) in redox biology and their potential as biomarkers and modulators of aging. She has authored numerous publications in the field and actively contributes to both teaching and scientific dissemination.