Host and microbiota derived extracellular vesicles: Crucial players in iron homeostasis
In a groundbreaking review, Prof. Marvin Edeas, founder of Targeting Extracellular Vesicles conference, shed light on the intricate relationship between extracellular vesicles (EVs), iron metabolism, and the gut microbiota.
Iron, a vital element for all living organisms, is a double-edged sword – essential for life, yet potentially fatal in deficiency or overload. Prof. Edeas’ review delves into the tightly regulated iron homeostasis at both cellular and systemic levels in humans.
In a significant breakthrough, the review highlights the emerging role of EVs, recognized as major players in cellular communication, in the regulation of iron metabolism. Specifically, the gut microbiota, a recent contender in impacting iron metabolism, is explored in-depth. The review addresses the crucial question of whether microbiota-derived EVs interfere in this intricate relationship.
Key findings of the review include:
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EVs’ Role in Iron Metabolism: EVs are unveiled as integral components in the complex iron metabolism process, carrying ferritin and expressing transferrin receptors.
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Microbiota’s Impact: The gut microbiota’s blooming role in iron homeostasis is discussed, with a focus on the potential contribution of EVs.
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Implications for Disease Treatment: Prof. Edeas concludes that targeting extracellular vesicles and gut microbiota-derived extracellular vesicles could present a substantial challenge in treating diseases associated with alterations in iron metabolism.
This groundbreaking review marks the first step towards unraveling the multiplex iron metabolism process, offering new insights that may pave the way for innovative therapeutic approaches in addressing diseases related to iron metabolism.
Stay tuned for further developments as the scientific community delves deeper into this groundbreaking research during Targeting Extracellular Vesicles 2024 Conference.
Image Credits: Daou et al. Front. Med. (2022)
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